No microscopic changes were observed in the testes of rats from either study. This may not be a complete list of all interactions that may occur. Ask your health care provider if Vytorin may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine. Initiate treatment as soon as possible but within 3 hours after symptom onset. Marakis G, Walker AF, Middleton RW, et al. Artichoke leaf extract reduces mild dyspepsia in an open study. persantine
Some received IV heparin on arrival to the emergency room prior to enrollment and randomization. Hikino, H. Antihepatotoxic principles of Atractylodes rhizomes. J Nat. The Physician must register to access tools and materials for patient support, product sample requests, up-to-date professional resources, and other Merck professional sites. Take Vytorin by mouth with or without food, preferably in the evening, unless directed otherwise by your doctor.
Vytorin should not be taken by pregnant women or nursing mothers. The comparative efficacy of these two regimens has not been evaluated. LDL-C, Apo B, TG, and non-HDL-C compared to simvastatin and significantly increased HDL-C compared to placebo. Barthel Index score of 95 or greater Modified Rankin Scale score of 1 or less Glasgow Outcome Scale score of 1 and NIHSS score of 1 or less.
The difference between the statin and combination therapy was modest, but significant. Ask your pharmacist how to dispose of medicines no longer required. It is very important that your doctor check your progress at regular visits. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to take it. Blood tests may be needed to check for unwanted effects.
Heckers H, Dittmar K, Schmahl FW, et al. Inefficiency of cynarin as therapeutic regimen in familial type II hyperlipoproteinaemia. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist. When such reactions occur, they usually respond to conventional therapy. AA can affect men, women, and children. It often appears as well-defined circular bald patches on the scalp. Many people will get just one or two patches, but for some the hair loss can be extensive. Unfortunately, children who develop AA before puberty are most likely to develop more extensive and persistent hair loss. Cuevas, M. Occupational contact urticaria syndrome caused by globe artichoke Cynara scolymus. J Allergy Clin Immunol. Should not be used in patients with these conditions. Tell your doctor if you regularly drink grapefruit juice. Drinking large amounts of grapefruit juice more than 1 quart each day while taking this medicine may increase your risk of muscle injury and could result in kidney problems. Vytorin is a combination of 2 medicines. Ezetimibe is an antihyperlipidemic agent. It works by reducing the amount of cholesterol that your body absorbs from your diet. Simvastatin is an HMG-CoA reductase inhibitor or "statin. Warnings: Pregnancy and breast-feeding: There is not enough reliable information about the safety of taking artichoke if you are pregnant or breast feeding. Stay on the safe side and avoid use. Bile duct obstruction: There is concern that artichoke might worsen bile duct obstruction by increasing bile flow. All patients recovered without sequelae. This drug may rarely cause muscle problems which can rarely lead to very serious conditions called rhabdomyolysis and autoimmune myopathy. Vytorin should be taken as a single daily dose in the evening, with or without food. Emilia, 21 27100-Pavia Italy. Fenofibrates may increase cholesterol excretion into the bile, leading to cholelithiasis.
Product Information. Zetia ezetimibe. Based on a meta-analysis of multiple-dose pharmacokinetic studies, there were no pharmacokinetic differences between Black and Caucasian subjects. Studies in Asian subjects indicated that the pharmacokinetics of ezetimibe was similar to those seen in Caucasian subjects. Kirchhoff R, Beckers CH, Kirchhoff GM, and et al. Increase in choleresis by means of artichoke extract. Simons LA "Simvastatin in severe primary hypercholesterolemia: efficacy, safety, and tolerability in 595 patients over 18 weeks. The Principal Investigators. In 4- to 12-week toxicity studies in mice, ezetimibe did not induce cytochrome P450 drug-metabolizing enzymes. In toxicity studies, a pharmacokinetic interaction of ezetimibe with statins parents or their active hydroxy acid metabolites was seen in rats, dogs, and rabbits. Inegy frequency not known. Each tablet contains 10 mg ezetimibe and 20 mg simvastatin. The tablets are not scored and should not be divided. WebMD User Reviews should not be considered as medical advice and are not a substitute for professional medical advice, diagnosis, or treatment. Never delay or disregard seeking professional medical advice from your physician or other qualified healthcare provider because of something you have read on WebMD. You should always speak with your doctor before you start, stop, or change any prescribed part of your care plan or treatment. WebMD understands that reading individual, real-life experiences may be a helpful health information resource but they are never a substitute for professional medical advice from a qualified healthcare provider. The cause of the increased risk of myopathy is not known. It is also unknown if the risk for myopathy with coadministration of simvastatin with lipid-modifying doses of niacin-containing products observed in Chinese patients applies to other Asian patients. Vytorin and placebo, respectively. This list is not complete and there are many other drugs that can cause serious or life threatening medical problems if you take them together with ezetimibe and simvastatin. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor. Keep a list of all your medicines and show it to any healthcare provider who treats you. PT was greater than 15 seconds or the activated partial thromboplastin time aPTT was elevated. Patients with prior aspirin use were included. Administration of anticoagulants and antiplatelet agents was prohibited for the first 24 hours following symptom onset. In rare cases, simvastatin can cause a condition that results in the breakdown of skeletal muscle tissue, leading to kidney failure. Call your doctor right away if you have unexplained muscle pain, tenderness, or weakness especially if you also have fever, unusual tiredness, and dark colored urine. cytotec
Monitor patients treated with Activase during and for several hours after infusion for orolingual angioedema. Open the package containing the transfer device by peeling the paper label off the package. Walshe, J. J. Renal failure associated with alternative medical therapies. Ren Fail. FDA product labels and may differ in countries outside the USA. Every effort has been made to ensure that the information provided on this page is accurate, up-to-date and complete, but no guarantee is made to that effect. Drugs. It is not known whether simvastatin is excreted in human milk. Because a small amount of another drug in this class is excreted in human milk and because of the potential for serious adverse reactions in nursing infants, women taking simvastatin should not nurse their infants. Aspirin and heparin have been administered concomitantly with and following infusions of Activase in the management of acute myocardial infarction and pulmonary embolism, but the concomitant administration of heparin and aspirin with and following infusions of Activase for the treatment of acute ischemic stroke during the first 24 hours after symptom onset has not been investigated. Because heparin, aspirin, or Activase may cause bleeding complications, carefully monitor for bleeding, especially at arterial puncture sites. Hemorrhage can occur 1 or more days after administration of Activase, while patients are still receiving anticoagulant therapy. Vytorin contains ezetimibe, a selective inhibitor of intestinal cholesterol and related phytosterol absorption, and simvastatin, an HMG-CoA reductase inhibitor. Ezetimibe is primarily metabolized in the small intestine and liver via glucuronide conjugation with subsequent biliary and renal excretion. Minimal oxidative metabolism has been observed in all species evaluated. The initial volume of distribution approximates plasma volume. The risk of myopathy, including rhabdomyolysis, is dose related. Warning: The facts and figures contained in these reports are accurate to the best of our capability; however, our metrics are only meant to augment your medical knowledge, and should never be used as the sole basis for selecting a new medication. As with any medical decision, be sure to work with your doctor to ensure the best choices are made for your condition. Treating high cholesterol along with a cholesterol-lowering diet. It may also be used for other conditions as determined by your doctor. Posted 29 Feb 2012 by Drugs. valacyclovir online pharmacy buy valacyclovir
Take this medication by mouth with or without food as directed by your doctor, usually once daily in the evening. In addition, an apparent hypersensitivity syndrome has been reported rarely that has included one or more of the following features: anaphylaxis, angioedema, lupus erythematous-like syndrome, polymyalgia rheumatica, dermatomyositis, vasculitis, purpura, thrombocytopenia, leukopenia, hemolytic anemia, positive ANA, ESR increase, eosinophilia, arthritis, arthralgia, urticaria, asthenia, photosensitivity, fever, chills, flushing, malaise, dyspnea, toxic epidermal necrolysis, erythema multiforme, including Stevens-Johnson syndrome. Adzet T. Action of an artichoke extract against carbon tetrachloride-induced hepatotoxicity in rats. For these reasons, FAERS case reports cannot be used to calculate incidence or estimates of risk for a particular product or compare risks between products. Note: Fraudulent online pharmacies may attempt to sell an illegal generic version of Vytorin. These medications may be counterfeit and potentially unsafe. If you purchase medications online, be sure you are buying from a reputable and valid online pharmacy. Ask your health care provider for advice if you are unsure about the online purchase of any medication. Avoid drinking alcohol. It can raise triglyceride levels and may increase your risk of liver damage. The hypocholesterolemic effect of ezetimibe was evaluated in cholesterol-fed Rhesus monkeys, dogs, rats, and mouse models of human cholesterol metabolism. Remove the protective cap from one end of the transfer device and keeping the vial of SWFI upright, insert the piercing pin vertically into the center of the stopper of the vial of SWFI. Exclusivity is the sole marketing rights granted by the FDA to a manufacturer upon the approval of a drug and may run simultaneously with a patent. Exclusivity periods can run from 180 days to seven years depending upon the circumstance of the exclusivity grant. Ezetimibe and simvastatin may also be used for purposes not listed in this medication guide. IV infusion for at least 48 hours; subsequent heparin therapy was at the physician's discretion. Eligibility did not depend on lipid levels. If you miss a dose, do not take an extra dose. Just resume your usual schedule. If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses. Ezetimibe reduces blood cholesterol by inhibiting the absorption of cholesterol by the small intestine. The molecular target of ezetimibe has been shown to be the sterol transporter, Niemann-Pick C1-Like 1 NPC1L1 which is involved in the intestinal uptake of cholesterol and phytosterols. The patient must also be a US resident. generic ketorolac online store
This medicine can harm an unborn baby or cause birth defects. Do not use if you are pregnant. Ask your doctor or pharmacist for advice before taking any medicine. Katznelson S "Effect of HMG-CoA reductase inhibitors on chronic allograft rejection. There are no adequate and well-controlled studies in pregnant women. Activase is indicated for use in acute myocardial infarction AMI for the reduction of mortality and reduction of the incidence of heart failure. Older adults may be more sensitive to the side effects of this medication, especially muscle problems. Keep container tightly closed. What is the most important information I should know about ezetimibe and simvastatin Vytorin? Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose. The presence of other medical problems may affect the use of this medicine. LDL apheresis or if such treatments are unavailable. Bleeding events other than intracranial hemorrhage were noted in the studies of AIS and were consistent with the general safety profile of Activase. order nimodipine online store canada nimodipine
The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. Always consult your doctor or healthcare specialist for medical advice. See 7. Drug Interactions. Always take this medicine exactly as your doctor or pharmacist has told you. Compositae family. Members of this family include ragweed, chrysanthemums, marigolds, daisies, and many others. If you have allergies, be sure to check with your healthcare provider before taking artichoke. Gallstones: Artichoke might make gallstones worse by increasing bile flow; use artichoke with caution. Bannwarth B, Miremont G, Papapietro PM "Lupuslike syndrome associated with simvastatin. Multiple-dose studies of ezetimibe coadministered with statins in rats and rabbits during organogenesis result in higher ezetimibe and statin exposures. Reproductive findings occur at lower doses in coadministration therapy compared to monotherapy. Rudski L, Rabinovitch MA, Danoff D "Systemic immune reactions to HMG-CoA reductase inhibitors - Report of 4 cases and review of the literature. Pharmacokinetic studies with another statin having a similar principal route of elimination to that of simvastatin have suggested that for a given dose level higher systemic exposure may be achieved in patients with severe renal impairment as measured by creatinine clearance. No animal carcinogenicity or fertility studies have been conducted with the combination of ezetimibe and simvastatin. The combination of ezetimibe with simvastatin did not show evidence of mutagenicity in vitro in a microbial mutagenicity Ames test with Salmonella typhimurium and Escherichia coli with or without metabolic activation. No evidence of clastogenicity was observed in vitro in a chromosomal aberration assay in human peripheral blood lymphocytes with ezetimibe and simvastatin with or without metabolic activation. These data do not include patients treated with the Activase accelerated infusion.
Vytorin is contraindicated in women who are or may become pregnant. Lipid-lowering drugs offer no benefit during pregnancy, because cholesterol and cholesterol derivatives are needed for normal fetal development. Atherosclerosis is a chronic process, and discontinuation of lipid-lowering drugs during pregnancy should have little impact on long-term outcomes of primary hypercholesterolemia therapy. There are no adequate and well-controlled studies of Vytorin use during pregnancy; however, there are rare reports of congenital anomalies in infants exposed to statins in utero. Animal reproduction studies of simvastatin in rats and rabbits showed no evidence of teratogenicity. Serum cholesterol and triglycerides increase during normal pregnancy, and cholesterol or cholesterol derivatives are essential for fetal development. Because statins, such as simvastatin, decrease cholesterol synthesis and possibly the synthesis of other biologically active substances derived from cholesterol, Vytorin may cause fetal harm when administered to a pregnant woman. If Vytorin is used during pregnancy or if the patient becomes pregnant while taking this drug, the patient should be apprised of the potential hazard to the fetus. Hg or lower for 24 hours. F. Protect the lyophilized material during extended storage from excessive exposure to light. The risk of myopathy, including rhabdomyolysis, occurring with use of Vytorin is increased when taking certain types of medication or consuming grapefruit juice. Patients should discuss all medication, both prescription and over the counter, with their healthcare professional. Cholesterol is one of several fatty substances found in the bloodstream. Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Negro, J. M. Occupational rhinitis and bronchial asthma due to artichoke Cynara scolymus. Ann Allergy Asthma Immunol. Activase can cause internal bleeding intracranial, retroperitoneal, gastrointestinal, genitourinary, respiratory or external bleeding, especially at arterial and venous puncture sites. Avoid intramuscular injections and trauma to the patient while on Activase. Perform venipunctures carefully and only as required. To minimize bleeding from noncompressible sites, avoid internal jugular and subclavian venous punctures. If an arterial puncture is necessary during Activase infusion, use an upper extremity vessel that is accessible to manual compression, apply pressure for at least 30 minutes, and monitor the puncture site closely. Activase to placebo Study 4 patients infused with Activase within 4 hours of onset of symptoms experienced improved left ventricular function at Day 10 compared to the placebo group, when ejection fraction was measured by gated blood pool scan 53. It is possible that some side effects of Vytorin may not have been reported. Following an oral dose of 14C-labeled simvastatin in man, 13% of the dose was excreted in urine and 60% in feces. Reduction in LDL-C was consistent across age, sex, and baseline LDL-C. ases.info casodex
The 1-year simvastatin arm enabled the comparison of Vytorin to simvastatin with regard to safety and effect on lipid levels. The following drugs can increase your risk of serious muscle problems if you take them together with simvastatin. Stahl, W. Screening pharmaceutical preparations containing extracts of turmeric rhizome, artichoke leaf, devil's claw root and garlic or salmon oil for antioxidant capacity. Vytorin when taking lomitapide. Does Vytorin 10-20 oral have side effects? Walker JF "Simvastatin: the clinical profile. AUC for total ezetimibe and ezetimibe increased approximately 4-fold compared to healthy subjects. Lowering "bad" cholesterol and triglycerides and raising "good" cholesterol decreases the risk of heart disease and helps prevent strokes and heart attacks. Plasma cholesterol is derived from intestinal absorption and endogenous synthesis. Vytorin contains ezetimibe and simvastatin, two lipid-lowering compounds with complementary mechanisms of action. Vytorin reduces elevated total-C, LDL-C, Apo B, TG, and non-HDL-C, and increases HDL-C through dual inhibition of cholesterol absorption and synthesis. Vytorin may cause dizziness. This effect may be worse if you take it with alcohol or certain medicines. Use Vytorin with caution. Do not keep outdated medicine or medicine no longer needed. Inegy is available in blister packs containing 28 tablets. The hair loss can be quite sudden, developing in a matter of a few days and it may happen anywhere on the scalp. The patch is usually smooth bald skin with nothing obvious to see beyond the absence of hair. The use of the Truven Health products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Truven Health and Drugs. purchase online clotrimazole mastercard
However, in studies with another structurally-related statin, skeletal malformations were observed in rats and mice. The treatment effect of Vytorin on MVE was attenuated among patients on dialysis at baseline compared with those not on dialysis at baseline. Its regulatory action on blood cholesterol and on blood lipoproteins in human atherosclerotic disease. Some MEDICINES MAY INTERACT with Vytorin. Keep Vytorin in a tightly closed container, and keep Vytorin out of light. Patent and Trademark Office and assigns exclusive legal right to the patent holder to protect the proprietary chemical formulation. The patent assigns exclusive legal right to the inventor or patent holder, and may include entities such as the drug brand name, trademark, product dosage form, ingredient formulation, or manufacturing process A patent usually expires 20 years from the date of filing, but can be variable based on many factors, including development of new formulations of the original chemical, and patent infringement litigation. Vytorin has been approved by the FDA. There are many other drugs that should not be used together with ezetimibe and simvastatin. Tell your doctor about all medications you use. Keep a list of all your medicines and show it to any healthcare provider who treats you. In the primary intent-to-treat analysis, 639 15. If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Electronic Code of Federal Regulations. Title 21. Part 182 -- Substances Generally Recognized As Safe. Statins, which lower the amount of LDL or bad cholesterol in the blood, are considered a kind of miracle drug in modern medicine. Among the most widely prescribed in the world, they are often able to lower a person's cholesterol to very low levels with few noticeable side effects. But they don't work for everyone and some can't tolerate a full dose -- they can cause muscle pain, digestive issues and liver damage -- and until now there haven't been any good alternatives. Kupke D, Sanden HV, Trinczek-Gartner H, and et al. Prüfung der choleretischen Aktivitat eines pflanzlichen Cholagogums. HMG-CoA reductase inhibitory activity increases the risk of myopathy and rhabdomyolysis, particularly with higher doses of Vytorin. Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of ezetimibe and simvastatin combination in children 10 to 17 years of age. However, safety and efficacy of ezetimibe and simvastatin combination in children younger than 10 years of age have not been established. buy lamictal online usa
COOR6; R6, R7 and R8 are H, lower alkyl or aryl-substituted Ic R9 is lower alkyl, aryl or aryl-substituted lower alkyl; are disclosed, as well as a method of lowering serum cholesterol by administering said compounds, alone or in combination with a cholesterol biosynthesis inhibitor, pharmaceutical compositions containing them; and a process for preparing them. Following administration of 100 mg Activase, there is a decrease 16%-36% in circulating fibrinogen. Weiland HH, Kindler K, Kranzl Ch, and et al. Uber den Einfluss von Cynarin auf Hyperlipidamien unter besonderer Berucksichtigung des Typs II Hypercholesterinamie. Do not take Inegy if”. This Patient Information summarizes the most important information about Vytorin. If you would like more information, talk with your doctor. You can ask your pharmacist or doctor for information about Vytorin that is written for health professionals. Do not add any other medication to infusion solutions containing Activase. Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Disclaimer: The indications, uses and warnings for individual medications outside the USA are determined by local regulatory bodies in each country or region. The Drugs. Simvastatin exposure is approximately doubled with concomitant use of lomitapide; therefore, the dose of Vytorin should be reduced by 50% if initiating lomitapide. Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver disease, kidney disease, alcohol use. Post-renal transplant patients with mild impaired or normal renal function. Two-tailed p-value is for comparison of Accelerated Activase to the respective SK control arm. Koldziej, B. Protective properties of artichoke Cynara scolymus against oxidative stress induced in cultured endothelial cells and monocytes. Life Sci. Muscle pain, tenderness and weakness myopathy. Muscle problems, including muscle breakdown, can be serious in some people and rarely cause kidney damage that can lead to death. Resources for HEALTHCARE PROFESSIONALS ONLY. imipramine
Acute pulmonary emboli obstructing blood flow to a lobe or multiple lung segments. In clinical studies in patients with AIS Studies 1 and 2 the incidence of intracranial hemorrhage, especially symptomatic intracranial hemorrhage, was higher in Activase-treated patients than in placebo patients. Tell your doctor if you are taking niacin or a niacin-containing product, as this may increase your risk of muscle problems, especially if you are Chinese. Vytorin needs to be initiated on an interacting drug that is contraindicated or is associated with a dose cap for simvastatin, that patient should be switched to an alternative statin or statin-based regimen with less potential for the drug-drug interaction. Patients should be advised of the increased risk of myopathy, including rhabdomyolysis, and to report promptly any unexplained muscle pain, tenderness or weakness. Medicare and insurance plans, but some pharmacy coupons or cash prices may be lower. The number of cases is adequate only to exclude a 3- to 4-fold increase in congenital anomalies over the background incidence. In 89% of the prospectively followed pregnancies, drug treatment was initiated prior to pregnancy and was discontinued at some point in the first trimester when pregnancy was identified. Acute Myocardial Infarction: Arrhythmias, AV block, cardiogenic shock, heart failure, cardiac arrest, recurrent ischemia, myocardial reinfarction, myocardial rupture, electromechanical dissociation, pericardial effusion, pericarditis, mitral regurgitation, cardiac tamponade, thromboembolism, pulmonary edema. These events may be life threatening and may lead to death. The interaction of Activase with other cardioactive or cerebroactive drugs has not been studied. Anticoagulants and antiplatelet drugs increase the risk of bleeding if administered prior to, during, or after Activase therapy. Simvastatin", "medicare_seo_page": "Medicare coverage and pricing details for Vytorin. Learn more about Medicare prescription drug plans and savings with GoodRx. Tell your doctor if you have severe lung disease. NDC 66582-311-82 bottles of 1000 If repackaged in blisters, then opaque or light-resistant blisters should be used. Federman DG, Hussain F, Walters AB "Fatal rhabdomyolysis caused by lipid-lowering therapy.
No specific treatment of overdosage with Vytorin can be recommended. In the event of an overdose, symptomatic and supportive measures should be employed. Swirl gently to dissolve the Activase powder. DO NOT SHAKE. You may need to take ezetimibe and simvastatin on a long-term basis for the treatment of high cholesterol. You may need to stop using simvastatin for a short time if you have surgery or a medical emergency. After oral administration, ezetimibe is absorbed and extensively conjugated to a pharmacologically active phenolic glucuronide ezetimibe-glucuronide. Take this medicine only as directed by your doctor. Do not use more of it, do not use it more often, and do not use it for a longer time than your doctor ordered. Fintelmann V. Therapeutic profile and mechanism of action of artichoke leaf extract: hypolipemic, antioxidant, hepatoprotective and choleretic properties. The availability of the β-hydroxyacid to the systemic circulation following an oral dose of simvastatin was found to be less than 5% of the dose, consistent with extensive hepatic first-pass extraction. Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in clinical practice. buy online phenergan
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These elevations in transaminases were generally asymptomatic, not associated with cholestasis, and returned to baseline after discontinuation of therapy or with continued treatment. Side effects cannot be anticipated. If any develop or change in intensity, tell your doctor as soon as possible. Only your doctor can determine if it is safe to continue using Vytorin. Side effects may include - Allergic reaction including swelling of the face, lips, throat, or tongue, difficulty breathing or swallowing, or rash; flu; gallstones; headache; inflammation of the gallbladder; inflammation of the liver; inflammation of the pancreas; muscle pain, tenderness, or weakness; nausea; numbness or pain in the hands or feet; upper respiratory infection.
Grapefruit and grapefruit juice may interact with simvastatin and lead to potentially dangerous effects. Do not drink more than 1 quart of grapefruit juice daily. Simvastatin and other High Cholesterol drugs at CVS, Walgreens, and other pharmacies. They seem to attack the hair follicles, mistakenly thinking that somehow they are a threat to the rest of the body. The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.
HeFH were randomized to receive either ezetimibe coadministered with simvastatin or simvastatin monotherapy. Active liver diseases or unexplained persistent transaminase elevations are contraindications to the use of Vytorin. Vials DO NOT USE IF VACUUM IS NOT PRESENT. Reference Listed Drug RLD is an approved drug product to which new generic versions are compared to show that they are bioequivalent. A drug company seeking approval to market a generic equivalent must refer to the Reference Listed Drug in its Abbreviated New Drug Application ANDA. By designating a single reference listed drug as the standard to which all generic versions must be shown to be bioequivalent, FDA hopes to avoid possible significant variations among generic drugs and their brand name counterpart.
In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345. Peces R, Pobes A "Rhabdomyolysis associated with concurrent use of simvastatin and diltiazem. Chan MH, Mak TW, Chiu RW, Chow CC, Chan IH, Lam CW "Simvastatin increases serum osteocalcin concentration in patients treated for hypercholesterolaemia. Schreiber VJ, Erb W, Wildgrube J, and Bohle E. Die fakale ausscheidung von gallensauren und lipiden des menschen bei normaler und medikamentos gesteigerter cholerese.